The independence of Portugal was recognised by the Holy See in the 12th century, by the bull Manifestis Probatum, issued by Pope Alexander III. In 1276 the Portuguese Pedro Hispano was elected Pope John XXI.
Relations reached their peak with the invaluable contribution by the Portuguese Crown and missionaries, in the centuries that followed, to the evangelization of the peoples of Africa, America and Asia.
The Church of Saint Anthony of the Portuguese, dedicated to the Saint, who was born in Lisbon in 1195 and died in Padua in 1231, has its origins in the initiatives of Guiomar de Lisboa (1363) and those of the Catedral Chapter of Lisbon to assist Portuguese pilgrims.
In 1440 Cardinal Antão Martins de Chaves, archpriest of the Basilica of Saint John Lateran, with autorization from Pope Paul II, founded the Hospice of the Portuguese Nation and a church in Campo Marzio. In the 17th century, this church was rebuilt in the Baroque style.
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